Synthesis and biological evaluation of novel quinazolin-4(3H)-one Schiff base derivatives as nitric oxide synthase inhibitors

Synthesis and biological evaluation of novel quinazolin-4(3H)-one Schiff base derivatives as nitric oxide synthase inhibitors

Synthesis of new Schiff base derivatives bearing a 6-nitro-2-ibuprofenyl-4(3H)-quinazolin-4-one skeleton, as well as their in vitro biological evaluation as inhibitors of nitric oxide synthase (iNOS and nNOS) isoforms, is defined. Structures of these novel heterocycles were confirmed based on their...

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Bibliographic Details
Main Authors:	Ayman M. Algohary, Mohamed M. Hassan
Format:	Article
Language:	English
Published:	Elsevier 2021-10-01
Series:	Arabian Journal of Chemistry
Subjects:	Quinazolinone Ibuprofen Arginine Inhibition Schiff Base
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535221003774

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