The Antidepressant-Like and Analgesic Effects of Kratom Alkaloids are accompanied by Changes in Low Frequency Oscillations but not ΔFosB Accumulation

The Antidepressant-Like and Analgesic Effects of Kratom Alkaloids are accompanied by Changes in Low Frequency Oscillations but not ΔFosB Accumulation

Mitragyna speciosa (“kratom”), employed as a traditional medicine to improve mood and relieve pain, has shown increased use in Europe and North America. Here, the dose-dependent effects of a purified alkaloid kratom extract on neuronal oscillatory systems function, analgesia, and antidepressant-like...

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Bibliographic Details
Main Authors: Shoshana Buckhalter, Eric Soubeyrand, Sarah A.E. Ferrone, Duncan J. Rasmussen, Joshua D. Manduca, M. Sameer Al-Abdul-Wahid, Jude A. Frie, Jibran Y. Khokhar, Tariq A. Akhtar, Melissa L. Perreault
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
kratom
neuronal oscillations
depression
analgesia
mitragynine
ΔFosB
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.696461/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.696461/full

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