Biased Immunoglobulin Genes Rearrangement in Mantle Cell Lymphoma: Hints to Identify the Normal B-cell Counterpart

Biased Immunoglobulin Genes Rearrangement in Mantle Cell Lymphoma: Hints to Identify the Normal B-cell Counterpart

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma, originating from naı ¨ve B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain (IgH) genes rearrangement for their importance in s...

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Bibliographic Details
Main Authors: Francesco Bertoni, Sergio B. Cogliatti, Daniela Capello, Xi-shan Hao, Hua-qing Wang, Hui-lai Zhang, Franco Cavalli
Format: Article
Language:English
Published: China Anti-Cancer Association 2011-06-01
Series:Cancer Biology & Medicine
Subjects:
mantle cell lymphoma
immunoglobulin genes
somatic hypermutation
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/47

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/47

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