Tacrolimus (FK506) suppresses TREM-1 expression at an early but not at a late stage in a murine model of fungal keratitis.

Tacrolimus (FK506) suppresses TREM-1 expression at an early but not at a late stage in a murine model of fungal keratitis.

To investigate the efficacy and mechanism of tacrolimus(FK506), which is a novel macrolide immunosuppressant, in inhibiting triggering receptor expressed on myeloid cells-1 (TREM-1) expression in a murine keratitis model induced by Aspergillus fumigatus.TREM-1 was detected in 11 fungus-infected huma...

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Bibliographic Details
Main Authors: Weilan Huang, Shiqi Ling, Xiuhua Jia, Binwu Lin, Xi Huang, Jing Zhong, Weihua Li, Xiaolei Lin, Yifang Sun, Jin Yuan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4252117?pdf=render

Internet

http://europepmc.org/articles/PMC4252117?pdf=render

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