Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

Dysregulated gene expression contributes to most prevalent features in human cancers. Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of MYB transcriptional co-activator complex. By rapid and selective peptidomimetic interference with the binding of C...

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Bibliographic Details
Main Authors: Sumiko Takao, Lauren Forbes, Masahiro Uni, Shuyuan Cheng, Jose Mario Bello Pineda, Yusuke Tarumoto, Paolo Cifani, Gerard Minuesa, Celine Chen, Michael G Kharas, Robert K Bradley, Christopher R Vakoc, Richard P Koche, Alex Kentsis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
Leukemia
gene expression
proteomics
Online Access:https://elifesciences.org/articles/65905

Internet

https://elifesciences.org/articles/65905

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