Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice[S]

Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice[S]

Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease tum...

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Bibliographic Details
Main Authors: Xiaoyun Tang, Matthew G.K. Benesch, Jay Dewald, Yuan Y. Zhao, Neeraj Patwardhan, Webster L. Santos, Jonathan M. Curtis, Todd P.W. McMullen, David N. Brindley
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Journal of Lipid Research
Subjects:
autotaxin
breast cancer
thyroid cancer
cell migration
epidermal growth factor receptor
G-protein-coupled receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520349907

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http://www.sciencedirect.com/science/article/pii/S0022227520349907

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