Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice.

Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice.

A positive relationship between obesity and asthma has been well documented. The AMP-activated protein kinase (AMPK) activator metformin reverses obesity-associated insulin resistance (IR) and inhibits different types of inflammatory responses. This study aimed to evaluate the effects of metformin o...

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Bibliographic Details
Main Authors: Marina Ciarallo Calixto, Letícia Lintomen, Diana Majoli André, Luiz Osório Leiria, Danilo Ferreira, Camilo Lellis-Santos, Gabriel Forato Anhê, Silvana Bordin, Richardt Gama Landgraf, Edson Antunes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3811997?pdf=render

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http://europepmc.org/articles/PMC3811997?pdf=render

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