A novel non-human primate model of Pelizaeus-Merzbacher disease

A novel non-human primate model of Pelizaeus-Merzbacher disease

Pelizaeus-Merzbacher disease (PMD) is a severe hypomyelinating disorder of the central nervous system (CNS) linked to mutations in the proteolipid protein-1 (PLP1) gene. Although there are multiple animal models of PMD, few of them fully mimic the human disease. Here, we report three spontaneous cas...

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Bibliographic Details
Main Authors: Larry S. Sherman, Weiping Su, Amanda L. Johnson, Samuel M. Peterson, Cassandra Cullin, Tiffany Lavinder, Betsy Ferguson, Anne D. Lewis
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Neurobiology of Disease
Subjects:
Pelizaeus-Merzbacher disease
Hypomyelination
Proteolipid protein
Oligodendrocytes
Non-human primate
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612100214X

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http://www.sciencedirect.com/science/article/pii/S096999612100214X

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