A 2,5-Dihydroxybenzoic Acid–Gelatin Conjugate Inhibits the Basal and Hsp90-Stimulated Migration and Invasion of Tumor Cells

A 2,5-Dihydroxybenzoic Acid–Gelatin Conjugate Inhibits the Basal and Hsp90-Stimulated Migration and Invasion of Tumor Cells

The extracellular cell surface-associated and soluble heat shock protein 90 (Hsp90) is known to participate in the migration and invasion of tumor cells. Earlier, we demonstrated that plasma membrane-associated heparan sulfate proteoglycans (HSPGs) bind the extracellular Hsp90 and thereby promote th...

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Bibliographic Details
Main Authors: Anastasiya V. Snigireva, Oleg S. Morenkov, Yuri Y. Skarga, Alexander V. Lisov, Zoya A. Lisova, Alexey A. Leontievsky, Mariya A. Zhmurina, Viktoria S. Petrenko, Veronika V. Vrublevskaya
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Journal of Functional Biomaterials
Subjects:
2,5-dihydroxybenzoic acid (2,5-DHBA)
2,5-DHBA–gelatin conjugate
heparin-like polymer
extracellular Hsp90
cell migration and invasion
Online Access:https://www.mdpi.com/2079-4983/11/2/39

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https://www.mdpi.com/2079-4983/11/2/39

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