Lactosylceramide contributes to mitochondrial dysfunction in diabetes

Lactosylceramide contributes to mitochondrial dysfunction in diabetes

Sphingolipids have been implicated as key mediators of cell-stress responses and effectors of mitochondrial function. To investigate potential mechanisms underlying mitochondrial dysfunction, an important contributor to diabetic cardiomyopathy, we examined alterations of cardiac sphingolipid metabol...

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Bibliographic Details
Main Authors: Sergei A. Novgorodov, Christopher L. Riley, Jin Yu, Jarryd A. Keffler, Christopher J. Clarke, An O. Van Laer, Catalin F. Baicu, Michael R. Zile, Tatyana I. Gudz
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Journal of Lipid Research
Subjects:
glycolipids
sphingolipids
calcium
heart
respiration
mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520354110

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http://www.sciencedirect.com/science/article/pii/S0022227520354110

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