The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial

The NAPRESSIM trial: the use of low-dose, prophylactic naloxone infusion to prevent respiratory depression with intrathecally administered morphine in elective hepatobiliary surgery: a study protocol and statistical analysis plan for a randomised controlled trial

Abstract Background Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required for effective analgesia currently limits its clini...

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Bibliographic Details
Main Authors: David Cosgrave, Marie Galligan, Era Soukhin, Victoria McMullan, Siobhan McGuinness, Anand Puttappa, Niamh Conlon, John Boylan, Rabia Hussain, Peter Doran, Alistair Nichol
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Trials
Subjects:
Intrathecal morphine
Naloxone
Respiratory depression
Randomised controlled trials
Online Access:http://link.springer.com/article/10.1186/s13063-017-2370-0

Internet

http://link.springer.com/article/10.1186/s13063-017-2370-0

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