Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

Abstract Retinal ganglion cell dendritic atrophy is an early feature of glaucoma, and the recovery of retinal ganglion cell dendrites is a viable option for vision improvement in glaucoma. Retinal ganglion cell neurites are surrounded by a specialised glycosaminoglycan extracellular matrix which inh...

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Bibliographic Details
Main Authors: James R. Tribble, Pete A. Williams, Bruce Caterson, Frank Sengpiel, James E. Morgan
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Molecular Brain
Subjects:
Retinal ganglion cell
Dendrite
Glaucoma
Neuro-protection
Chondroitinase ABC
Glycosaminoglycan
Online Access:http://link.springer.com/article/10.1186/s13041-018-0412-5

Internet

http://link.springer.com/article/10.1186/s13041-018-0412-5

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