Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation

Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation

The adaptive immune response involves T cell differentiation and migration to sites of inflammation. T cell trafficking is initiated by rolling on inflamed endothelium. Tethers and slings, discovered in neutrophils, facilitate cell rolling at high shear stress. Here, we demonstrate that the ability...

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Bibliographic Details
Main Authors: Michael Abadier, Akula Bala Pramod, Sara McArdle, Alex Marki, Zhichao Fan, Edgar Gutierrez, Alex Groisman, Klaus Ley
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
CD4 T cell subsets
rolling
P-selectin
E-selectin
PSGL-1
tethers
slings
RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317837

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717317837

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