The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB

The Traditional Japanese Herbal Medicine Hachimijiogan Elicits Neurite Outgrowth Effects in PC12 Cells and Improves Cognitive in AD Model Rats via Phosphorylation of CREB

Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we describe that HJG a...

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Bibliographic Details
Main Authors: Kaori Kubota, Haruka Fukue, Hitomi Sato, Kana Hashimoto, Aya Fujikane, Hiroshi Moriyama, Takuya Watanabe, Shutaro Katsurabayashi, Mosaburo Kainuma, Katsunori Iwasaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
Hachimijiogan
neurotrophic factors
CREB
PC12 cells
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00850/full

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http://journal.frontiersin.org/article/10.3389/fphar.2017.00850/full

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