The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling

Complex interplay between cardiac tissues is crucial for their integrity. The flow responsive transcription factor KLF2, which is expressed in the endocardium, is vital for cardiovascular development but its exact role remains to be defined. To this end, we mutated both klf2 paralogues in zebrafish,...

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Bibliographic Details
Main Authors: Seyed Javad Rasouli, Mohamed El-Brolosy, Ayele Taddese Tsedeke, Anabela Bensimon-Brito, Parisa Ghanbari, Hans-Martin Maischein, Carsten Kuenne, Didier Y Stainier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
Klf2
cell extrusion
cardiomyocyte behavior
myocardial wall integrity
zebrafish heart development
Fgf signaling
Online Access:https://elifesciences.org/articles/38889

Internet

https://elifesciences.org/articles/38889

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