Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane

Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane

Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host cell plasma membrane. VP40 traffics to the pla...

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Bibliographic Details
Main Authors: Kaveesha J. Wijesinghe, Luke McVeigh, Monica L. Husby, Nisha Bhattarai, Jia Ma, Bernard S. Gerstman, Prem P. Chapagain, Robert V. Stahelin
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Viruses
Subjects:
ebola virus
filovirus
lipid binding
marburg virus
membrane trafficking
virus assembly
Online Access:https://www.mdpi.com/1999-4915/12/4/482

Internet

https://www.mdpi.com/1999-4915/12/4/482

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