Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.

Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.

The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory m...

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Bibliographic Details
Main Authors: Kushol Gupta, Vesa Turkki, Scott Sherrill-Mix, Young Hwang, Grant Eilers, Louis Taylor, Charlene McDanal, Ping Wang, David Temelkoff, Robert T Nolte, Emile Velthuisen, Jerry Jeffrey, Gregory D Van Duyne, Frederic D Bushman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5147827?pdf=render

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