Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer

Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer

The prostate cancer (PCa) field lacks clinically relevant, syngeneic mouse models which retain the tumour microenvironment observed in PCa patients. This study establishes a cell line from prostate tumour tissue derived from the <i>Pten<sup>−/−</sup>/trp53<sup>−/−</sup>...

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Bibliographic Details
Main Authors: Charles M. Haughey, Debayan Mukherjee, Rebecca E. Steele, Amy Popple, Lara Dura-Perez, Adam Pickard, Mehjabin Patel, Suneil Jain, Paul B. Mullan, Rich Williams, Pedro Oliveira, Niamh E. Buckley, Jamie Honeychurch, Simon S. McDade, Timothy Illidge, Ian G. Mills, Sharon L. Eddie
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
tumour microenvironment
syngeneic model
prostate cancer
radiotherapy
preclinical modelling
myeloid-derived suppressor cells
Online Access:https://www.mdpi.com/2072-6694/12/10/2804

Internet

https://www.mdpi.com/2072-6694/12/10/2804

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