Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes.

Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes.

BACKGROUND:The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an important role in the development and progression of fibrosis in many organ systems, including liver. However, its role in the pathogenesis of hepatitis C virus (HCV)-induced liver fibrosis remains unclear. METHOD...

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Bibliographic Details
Main Authors: Tirumuru Nagaraja, Li Chen, Anuradha Balasubramanian, Jerome E Groopman, Kalpana Ghoshal, Samson T Jacob, Andrew Leask, David R Brigstock, Appakkudal R Anand, Ramesh K Ganju
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3464290?pdf=render

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http://europepmc.org/articles/PMC3464290?pdf=render

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