Autofluorescence enhancement for label-free imaging of myelinated fibers in mammalian brains

Abstract Analyzing the structure of neuronal fibers with single axon resolution in large volumes is a challenge in connectomics. Different technologies try to address this goal; however, they are limited either by the ineffective labeling of the fibers or in the achievable resolution. The possibilit...

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Bibliographic Details
Main Authors: Irene Costantini, Enrico Baria, Michele Sorelli, Felix Matuschke, Francesco Giardini, Miriam Menzel, Giacomo Mazzamuto, Ludovico Silvestri, Riccardo Cicchi, Katrin Amunts, Markus Axer, Francesco Saverio Pavone
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86092-7