Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30

Abstract Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. Accumulating experimental evidence suggests that some metal compounds have the potential to induce cancer cell death via inhibition of DUBs. We previously reported that auranofin, a gold(I)-containin...

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Bibliographic Details
Main Authors: Ding Yan, Xiaofen Li, Qianqian Yang, Qingtian Huang, Leyi Yao, Peiquan Zhang, Wenshuang Sun, Shuhui Lin, Q. Ping Dou, Jinbao Liu, Xin Chen
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00599-6