An Improved Helferich Method for the α/β-Stereoselective Synthesis of 4-Methylumbelliferyl Glycosides for the Detection of Microorganisms

An Improved Helferich Method for the α/β-Stereoselective Synthesis of 4-Methylumbelliferyl Glycosides for the Detection of Microorganisms

An improved Helferich method is presented. It involves the glycosylation of 4-methyl-umbelliferone with glycosyl acetates in the presence of boron trifluoride etherate combined with triethylamine, pyridine, or 4-dimethylaminopyridine under mild conditions, followed by deprotection to give fluorogeni...

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Bibliographic Details
Main Authors: Xianhu Wei, Yanxia Ma, Qingping Wu, Jumei Zhang, Zhihe Cai, Mianfei Lu
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
fluorogenic substrates
4-methylumbelliferyl glycosides
stereoselective glycosylation
glycosyl acetates
peracetyl sugars
Online Access:http://www.mdpi.com/1420-3049/20/12/19789

Internet

http://www.mdpi.com/1420-3049/20/12/19789

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