Cationic liposomes induce cytotoxicity in HepG2 via regulation of lipid metabolism based on whole-transcriptome sequencing analysis

Cationic liposomes induce cytotoxicity in HepG2 via regulation of lipid metabolism based on whole-transcriptome sequencing analysis

Abstract Backgroud Cationic liposomes (CLs) can be used as non-viral vectors in gene transfer and drug delivery. However, the underlying molecular mechanism of its cytotoxicity has not been well elucidated yet. Methods We herein report a systems biology approach based on whole-transcriptome sequenci...

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Bibliographic Details
Main Authors: Ying Li, Xiu-Liang Cui, Qing-Shan Chen, Jing Yu, Hai Zhang, Jie Gao, Du-Xin Sun, Guo-Qing Zhang
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Pharmacology and Toxicology
Subjects:
Cationic liposomes
Nanoparticle
Cytotoxicity
RNA-seq
Lipid metabolism
Online Access:http://link.springer.com/article/10.1186/s40360-018-0230-5

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http://link.springer.com/article/10.1186/s40360-018-0230-5

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