Antibodies to the Muscarinic Acetylcholine Receptor M3 in Primary Biliary Cholangitis Inhibit Receptor Function on Cholangiocytes

Antibodies to the Muscarinic Acetylcholine Receptor M3 in Primary Biliary Cholangitis Inhibit Receptor Function on Cholangiocytes

Background and Aims: In primary biliary cholangitis (PBC), antibodies to a peptide of the muscarinic acetylcholine receptor 3 (mAChR3) have been described. Since the mAChR3 is expressed on cholangiocytes and mAChR3-signaling is involved in the pathogenesis of chronic inflammatory biliary diseases, w...

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Bibliographic Details
Main Authors: Christian Mayer, Beate Preuss, Julia Grottenthaler, Christoph Berg, Reinhild Klein
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
primary biliary cholangitis
functional autoantibodies
muscarinic acetylcholine receptor 3
cholangiocytes
Chinese hamster ovary cells
disease activity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01151/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01151/full

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