Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

Neuropeptide Y signalling in the periphery contributes to the regulation of metabolic and energy homeostasis. Here the authors show that blocking Y1R signalling in peripheral tissues using the selective antagonist BIBO3304 ameliorates diet-induced obesity and improves whole-body glucose metabolism.

Bibliographic Details
Main Authors: Chenxu Yan, Tianshu Zeng, Kailun Lee, Max Nobis, Kim Loh, Luoning Gou, Zefeng Xia, Zhongmin Gao, Mohammed Bensellam, Will Hughes, Jackie Lau, Lei Zhang, Chi Kin Ip, Ronaldo Enriquez, Hanyu Gao, Qiao-Ping Wang, Qi Wu, Jody J. Haigh, D. Ross Laybutt, Paul Timpson, Herbert Herzog, Yan-Chuan Shi
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22925-3
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spelling doaj-2c59ad7667ab430db0c8a9a63837c5172021-05-11T14:48:46ZengNature Publishing GroupNature Communications2041-17232021-05-0112112010.1038/s41467-021-22925-3Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesityChenxu Yan0Tianshu Zeng1Kailun Lee2Max Nobis3Kim Loh4Luoning Gou5Zefeng Xia6Zhongmin Gao7Mohammed Bensellam8Will Hughes9Jackie Lau10Lei Zhang11Chi Kin Ip12Ronaldo Enriquez13Hanyu Gao14Qiao-Ping Wang15Qi Wu16Jody J. Haigh17D. Ross Laybutt18Paul Timpson19Herbert Herzog20Yan-Chuan Shi21Neuroscience Division, Garvan Institute of Medical Research, St Vincent’s HospitalWuhan Union Hospital, Huazhong University of Science and TechnologyNeuroscience Division, Garvan Institute of Medical Research, St Vincent’s HospitalInvasion and Metastasis Lab, Cancer Division, Garvan Institute of Medical Research, St Vincent’s HospitalNeuroscience Division, Garvan Institute of Medical Research, St Vincent’s HospitalWuhan Union Hospital, Huazhong University of Science and TechnologyWuhan Union Hospital, Huazhong University of Science and TechnologyDiabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s HospitalDiabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s HospitalDiabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s HospitalNeuroscience Division, Garvan Institute of Medical Research, St Vincent’s HospitalNeuroscience Division, Garvan Institute of Medical Research, St Vincent’s HospitalNeuroscience Division, Garvan Institute of Medical Research, St Vincent’s HospitalNeuroscience Division, Garvan Institute of Medical Research, St Vincent’s HospitalDiabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s HospitalSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen UniversityDiabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s HospitalResearch Institute in Oncology and Hematology, Department of Pharmacology and Therapeutics, University of ManitobaDiabetes and Metabolism Division, Garvan Institute of Medical Research, St Vincent’s HospitalInvasion and Metastasis Lab, Cancer Division, Garvan Institute of Medical Research, St Vincent’s HospitalNeuroscience Division, Garvan Institute of Medical Research, St Vincent’s HospitalNeuroscience Division, Garvan Institute of Medical Research, St Vincent’s HospitalNeuropeptide Y signalling in the periphery contributes to the regulation of metabolic and energy homeostasis. Here the authors show that blocking Y1R signalling in peripheral tissues using the selective antagonist BIBO3304 ameliorates diet-induced obesity and improves whole-body glucose metabolism.https://doi.org/10.1038/s41467-021-22925-3
collection DOAJ
language English
format Article
sources DOAJ
author Chenxu Yan
Tianshu Zeng
Kailun Lee
Max Nobis
Kim Loh
Luoning Gou
Zefeng Xia
Zhongmin Gao
Mohammed Bensellam
Will Hughes
Jackie Lau
Lei Zhang
Chi Kin Ip
Ronaldo Enriquez
Hanyu Gao
Qiao-Ping Wang
Qi Wu
Jody J. Haigh
D. Ross Laybutt
Paul Timpson
Herbert Herzog
Yan-Chuan Shi
spellingShingle Chenxu Yan
Tianshu Zeng
Kailun Lee
Max Nobis
Kim Loh
Luoning Gou
Zefeng Xia
Zhongmin Gao
Mohammed Bensellam
Will Hughes
Jackie Lau
Lei Zhang
Chi Kin Ip
Ronaldo Enriquez
Hanyu Gao
Qiao-Ping Wang
Qi Wu
Jody J. Haigh
D. Ross Laybutt
Paul Timpson
Herbert Herzog
Yan-Chuan Shi
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
Nature Communications
author_facet Chenxu Yan
Tianshu Zeng
Kailun Lee
Max Nobis
Kim Loh
Luoning Gou
Zefeng Xia
Zhongmin Gao
Mohammed Bensellam
Will Hughes
Jackie Lau
Lei Zhang
Chi Kin Ip
Ronaldo Enriquez
Hanyu Gao
Qiao-Ping Wang
Qi Wu
Jody J. Haigh
D. Ross Laybutt
Paul Timpson
Herbert Herzog
Yan-Chuan Shi
author_sort Chenxu Yan
title Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
title_short Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
title_full Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
title_fullStr Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
title_full_unstemmed Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
title_sort peripheral-specific y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description Neuropeptide Y signalling in the periphery contributes to the regulation of metabolic and energy homeostasis. Here the authors show that blocking Y1R signalling in peripheral tissues using the selective antagonist BIBO3304 ameliorates diet-induced obesity and improves whole-body glucose metabolism.
url https://doi.org/10.1038/s41467-021-22925-3
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