Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice

Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice

Herpes simplex virus-2 (HSV-2) is a leading cause of sexually transmitted infections for which no effective vaccines or prophylactic treatment currently exist. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor involved in the detoxification of reactive oxygen species (ROS)...

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Bibliographic Details
Main Authors: Camilla Gunderstofte, Marie Beck Iversen, Suraj Peri, Anne Thielke, Siddharth Balachandran, Christian Kanstrup Holm, David Olagnier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
Nrf2
antiviral immunity
innate immune responses
type I IFN
herpes virus
HSV
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02101/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02101/full

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