Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products

Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products

Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of secondary metabolites. However, this strain mainly pro...

Full description

Bibliographic Details
Main Authors:	Qian Wei, Jian Bai, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu, Youcai Hu
Format:	Article
Language:	English
Published:	Elsevier 2021-02-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Endophytic fungi Penicillium dangeardii Genome mining Silent gene cluster Azaphilones Trimers
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383520306626

Similar Items

A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2
by: Chao Yuan, et al.
Published: (2021-08-01)

Characterization of an Endophytic Strain Talaromyces assiutensis, CPEF04 With Evaluation of Production Medium for Extracellular Red Pigments Having Antimicrobial and Anticancer Properties
by: Rahul Chandra Mishra, et al.
Published: (2021-08-01)

Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale
by: Ken-ichi Nakashima, et al.
Published: (2020-08-01)

A New Azaphilone, Kasanosin C, from an Endophytic Talaromyces sp. T1BF
by: Liang-Qun Li, et al.
Published: (2010-06-01)

Structures of meroterpenes produced by Penicillium sp, an endophytic fungus found associated with Melia azedarach
by: Santos Regina M. Geris dos, et al.
Published: (2003-01-01)

A New Polyketide from the Endophytic Fungus <i>Penicillium chermesinum</i>
by: Cici Darsih, et al.
Published: (2017-11-01)

Asperlones A and B, Dinaphthalenone Derivatives from a Mangrove Endophytic Fungus Aspergillus sp. 16-5C
by: Ze'en Xiao, et al.
Published: (2015-01-01)

Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328#
by: Yanhong Ma, et al.
Published: (2015-10-01)

Deletion of the Histone Deacetylase HdaA in Endophytic Fungus <i>Penicillium chrysogenum</i> Fes1701 Induces the Complex Response of Multiple Bioactive Secondary Metabolite Production and Relevant Gene Cluster Expression
by: Zhuang Ding, et al.
Published: (2020-08-01)

Di-(2-ethylhexyl)phthalate and Pyranon Derivated from Endophytic fungi <i>Penicillium</i> sp the Leave of Kunyit Putih (<i>Curcuma zedoaria</i>)
by: Muharni Muharni, et al.
Published: (2014-10-01)

Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S
by: Bin-Gui Wang, et al.
Published: (2010-12-01)

New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54
by: Liuming Qiu, et al.
Published: (2018-03-01)

Dereplication, Annotation, and Characterization of 74 Potential Antimicrobial Metabolites from <i>Penicillium Sclerotiorum</i> Using t-SNE Molecular Networks
by: Téo Hebra, et al.
Published: (2021-07-01)

Response Surface Methodology Optimization of an Acidic Protease Produced by Penicillium bilaiae Isolate TDPEF30, a Newly Recovered Endophytic Fungus from Healthy Roots of Date Palm Trees (Phoenix dactylifera L.)
by: Fedia Ben Mefteh, et al.
Published: (2019-03-01)

Production, bioprocess optimization and γ-irradiation of Penicillium polonicum, as a new Taxol producing endophyte from Ginko biloba
by: Sobhy S. Abdel-Fatah, et al.
Published: (2021-06-01)

Esteroides produzidos por Penicillium herquei, um fungo endofítico isolado dos frutos de Melia azedarach (Meliaceae) Steroids produced by Penicillium herquei, an endophytic fungus isolated from the fruits of Melia azedarach (Meliaceae)
by: Andrey Moacir do Rosario Marinho, et al.
Published: (2009-01-01)

Exploring the diversity of endophytic fungi and screening for their pullulanase-producing capabilities
by: Bindu Naik, et al.
Published: (2021-07-01)

ONE STRAIN-MANY COMPOUNDS (OSMAC) METHOD FOR PRODUCTION OF PHENOLIC COMPOUNDS USING Camarops sp., AN ENDOPHYTIC FUNGUS FROM Alibertia macrophylla (Rubiaceae)
by: Juliana R. Gubiani, et al.

Chemical Constituents of a Marine-Derived Endophytic Fungus Penicillium commune G2M
by: Hui-Jiao Yan, et al.
Published: (2010-05-01)

Endophytic fungi mediated synthesis of iron nanoparticles: Characterization and application in methylene blue decolorization
by: Parikshana Mathur, et al.
Published: (2021-01-01)

Azaphilones from the Marine Sponge-Derived Fungus <i>Penicillium sclerotiorum</i> OUCMDZ-3839
by: Qian Jia, et al.
Published: (2019-04-01)

Ent-homocyclopiamine B, a Prenylated Indole Alkaloid of Biogenetic Interest from the Endophytic Fungus Penicillium concentricum
by: Tehane Ali, et al.
Published: (2019-01-01)

Penicitroamide, an Antimicrobial Metabolite with High Carbonylization from the Endophytic Fungus Penicillium sp. (NO. 24)
by: Zi-Wei Feng, et al.
Published: (2016-10-01)

Larvicidal effects of endophytic and basidiomycete fungus extracts on Aedes and Anopheles larvae (Diptera, Culicidae)
by: Augusto Bucker, et al.
Published: (2013-08-01)

Restoring Waning Production of Volatile Organic Compounds in the Endophytic Fungus Hypoxylon sp. (BS15)
by: Yuemin Wang, et al.
Published: (2018-06-01)

Antibacterial Activity of Endophytic Fungus Isolates of Mangrove Fruit (Sonneratia alba) Against Staphylococcus aureus and Esherichia coli
by: Sesilia Rante Pakadang, et al.
Published: (2021-06-01)

Detection and Characterization of Antibacterial Siderophores Secreted by Endophytic Fungi from <i>Cymbidium aloifolium</i>
by: Srinivas Chowdappa, et al.
Published: (2020-10-01)

Identification and Characterization of Unreported Penicillium Species in Korea
by: Doo-Ho Choi, et al.
Published: (2020-12-01)

Secondary metabolite (antibiotic) production by Indonesian endophytic fungi
by: Sebastian Margino
Published: (2008-04-01)

Enhancement of Thiamine Biosynthesis in Oil Palm Seedlings by Colonization of Endophytic Fungus Hendersonia toruloidea
by: Amirah N. Kamarudin, et al.
Published: (2017-10-01)

Antimicrobial Meroterpenoids and Erythritol Derivatives Isolated from the Marine-Algal-Derived Endophytic Fungus <i>Penicillium chrysogenum</i> XNM-12
by: Kuo Xu, et al.
Published: (2020-11-01)

Grovesiella abieticola (Tympanidaceae): an Unrecorded Endophytic Fungus from South Korea
by: Ju-Kyeong Eo, et al.
Published: (2020-06-01)

Production of secondary metabolite E2.2 from Phaleria macrocarpa endophytic fungus
by: Beatrix Trikurnia Gasong, et al.
Published: (2016-10-01)

PHYTOTOXIC CONSTITUENTS FROM ENDOPHYTIC FUNGUS Xylaria cubensis ASSOCIATED WITH Eugenia brasiliensis
by: Carolina R. Biasetto, et al.

Screening and production of lovastatin producing endophytic fungus from phyllanthus reticulatus using oyster mushroom extract
by: Gurusamy, G., et al.
Published: (2021)

Anti-mycobacterial activity of polyketides from Penicillium sp. endophyte isolated from Garcinia nobilis against Mycobacterium smegmatis
by: Jean Bosco Jouda, et al.
Published: (2016-01-01)

Two New Chroman Derivations from the Endophytic Penicillium sp. DCS523
by: Qi Wang, et al.
Published: (2011-01-01)

ENDOPHYTIC FUNGI IN Paraserianthes falcataria: PRODUCTION OF INDOLE ACETIC ACID
by: REINE SUCI WULANDARI, et al.
Published: (2019-08-01)

Prospecting the antimicrobial and antibiofilm potential of Chaetomium globosum an endophytic fungus from Moringa oleifera
by: Navdeep Kaur, et al.
Published: (2020-11-01)

Isolation and Identification of Fungal Endophytes of the Cowpea in Khuzestan Province
by: Sahar Jonbozorgi, et al.
Published: (2019-03-01)