Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products

Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products

Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of secondary metabolites. However, this strain mainly pro...

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Bibliographic Details
Main Authors: Qian Wei, Jian Bai, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu, Youcai Hu
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Endophytic fungi
Penicillium dangeardii
Genome mining
Silent gene cluster
Azaphilones
Trimers
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520306626

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http://www.sciencedirect.com/science/article/pii/S2211383520306626

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