Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide

Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide

Cell-penetrating peptide [WR]<sub>5</sub> has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one lysine to enable the co...

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Bibliographic Details
Main Authors: Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Shang Eun Park, Keykavous Parang, Rakesh Kumar Tiwari
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
cell-penetrating peptide
conjugate
camptothecin
cytotoxicity
MCF-7
paclitaxel
solubility
Online Access:https://www.mdpi.com/1420-3049/24/7/1427

Internet

https://www.mdpi.com/1420-3049/24/7/1427

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