PPARγ agonists improve survival and neurocognitive outcomes in experimental cerebral malaria and induce neuroprotective pathways in human malaria.

PPARγ agonists improve survival and neurocognitive outcomes in experimental cerebral malaria and induce neuroprotective pathways in human malaria.

Cerebral malaria (CM) is associated with a high mortality rate, and long-term neurocognitive impairment in approximately one third of survivors. Adjunctive therapies that modify the pathophysiological processes involved in CM may improve outcome over anti-malarial therapy alone. PPARγ agonists have...

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Bibliographic Details
Main Authors: Lena Serghides, Chloe R McDonald, Ziyue Lu, Miriam Friedel, Cheryl Cui, Keith T Ho, Howard T J Mount, John G Sled, Kevin C Kain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24603727/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24603727/?tool=EBI

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