Comparison of Gene Expression by Sheep and Human Blood Stimulated with the TLR4 Agonists Lipopolysaccharide and Monophosphoryl Lipid A.

Comparison of Gene Expression by Sheep and Human Blood Stimulated with the TLR4 Agonists Lipopolysaccharide and Monophosphoryl Lipid A.

Animal models that mimic human biology are important for successful translation of basic science discoveries into the clinical practice. Recent studies in rodents have demonstrated the efficacy of TLR4 agonists as immunomodulators in models of infection. However, rodent models have been criticized f...

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Bibliographic Details
Main Authors: Perenlei Enkhbaatar, Christina Nelson, John R Salsbury, Joseph R Carmical, Karen E O Torres, David Herndon, Donald S Prough, Liming Luan, Edward R Sherwood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4671644?pdf=render

Internet

http://europepmc.org/articles/PMC4671644?pdf=render

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