Comparative Analysis of the CDR Loops of Antigen Receptors

Comparative Analysis of the CDR Loops of Antigen Receptors

The adaptive immune system uses two main types of antigen receptors: T-cell receptors (TCRs) and antibodies. While both proteins share a globally similar β-sandwich architecture, TCRs are specialized to recognize peptide antigens in the binding groove of the major histocompatibility complex, while a...

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Bibliographic Details
Main Authors: Wing Ki Wong, Jinwoo Leem, Charlotte M. Deane
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
T-cell receptors
antibodies
loop conformations
protein structure prediction
NGS
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02454/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02454/full

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