miR-214-Dependent Increase of PHLPP2 Levels Mediates the Impairment of Insulin-Stimulated Akt Activation in Mouse Aortic Endothelial Cells Exposed to Methylglyoxal

miR-214-Dependent Increase of PHLPP2 Levels Mediates the Impairment of Insulin-Stimulated Akt Activation in Mouse Aortic Endothelial Cells Exposed to Methylglyoxal

Evidence has been provided linking microRNAs (miRNAs) and diabetic complications, by the regulation of molecular pathways, including insulin-signaling, involved in the pathophysiology of vascular dysfunction. Methylglyoxal (MGO) accumulates in diabetes and is associated with cardiovascular complicat...

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Bibliographic Details
Main Authors: Cecilia Nigro, Paola Mirra, Immacolata Prevenzano, Alessia Leone, Francesca Fiory, Michele Longo, Serena Cabaro, Francesco Oriente, Francesco Beguinot, Claudia Miele
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
miRNAs
endothelium
insulin resistance
diabetes mellitus
methylglyoxal
Online Access:http://www.mdpi.com/1422-0067/19/2/522

Internet

http://www.mdpi.com/1422-0067/19/2/522

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