A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos Medicinal chemistry of N-acylhydrazones: novel lead-compounds of analgesic, antiinflammatory and antithrombotic drugs

A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos Medicinal chemistry of N-acylhydrazones: novel lead-compounds of analgesic, antiinflammatory and antithrombotic drugs

<abstract language="eng">In this article are described new bioactive N-acylhydrazone (NAH) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e.g. CBS-1108 and BW-755c. The analgesic, a...

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Bibliographic Details
Main Authors: Eliezer J. Barreiro, Carlos A. M. Fraga, Ana L. P. Miranda, Carlos R. Rodrigues
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2002-02-01
Series:Química Nova
Subjects:
bioactive N-acylhydrazones derivatives
antiinflammatory, analgesic and antithrombotic properties
molecular hybridization and bioisosterism in drug design
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000100022

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000100022

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