Early evidence of delayed oligodendrocyte maturation in the mouse model of mucolipidosis type IV

Early evidence of delayed oligodendrocyte maturation in the mouse model of mucolipidosis type IV

Mucolipidosis type IV (MLIV) is a lysosomal disease caused by mutations in the MCOLN1 gene that encodes the endolysosomal transient receptor potential channel mucolipin-1, or TRPML1. MLIV results in developmental delay, motor and cognitive impairments, and vision loss. Brain abnormalities include th...

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Bibliographic Details
Main Authors: Molly Mepyans, Livia Andrzejczuk, Jahree Sosa, Sierra Smith, Shawn Herron, Samantha DeRosa, Susan A. Slaugenhaupt, Albert Misko, Yulia Grishchuk, Kirill Kiselyov
Format: Article
Language:English
Published: The Company of Biologists 2020-07-01
Series:Disease Models & Mechanisms
Subjects:
mucolipidosis type iv
lysosome
trpml1
mucolipin-1
myelination
oligodendrocyte
Online Access:http://dmm.biologists.org/content/13/7/dmm044230

Internet

http://dmm.biologists.org/content/13/7/dmm044230

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