Improvement of clavulanic acid production in Streptomyces clavuligerus F613-1 by using a claR-neo reporter strategy

Improvement of clavulanic acid production in Streptomyces clavuligerus F613-1 by using a claR-neo reporter strategy

Background: Streptomyces clavuligerus was the producer of clavulanic acid, claR, a pathway-specific transcriptional regulator in S. clavuligerus, positively regulates clavulanic acid biosynthesis. In this study, the promoter-less kanamycin resistance gene neo was fused with claR to obtain strain NEO...

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Bibliographic Details
Main Authors: Ronghuo Qin, Chuanqing Zhong, Gongli Zong, Jiafang Fu, Xiuhua Pang, Guangxiang Cao
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Electronic Journal of Biotechnology
Subjects:
claR
Clavulanic acid biosynthesis
Co-transcription
Fermentation
Fusion
Kanamycin
Mutagenesis
Mutagens
Promoter-less
Reporter gene
Transcriptional regulator
Online Access:http://www.sciencedirect.com/science/article/pii/S0717345817300246

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http://www.sciencedirect.com/science/article/pii/S0717345817300246

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