Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity

Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity

Guaianolides are pharmaceutically interesting molecules. Here, the authors isolate the enzyme kauniolide synthase from feverfew, show that it converts constunolide into a guaianolide via an unusual mechanism of action, and reconstruct the full kauniolide biosynthesis pathway in host organisms.

Bibliographic Details
Main Authors: Qing Liu, Arman Beyraghdar Kashkooli, David Manzano, Irini Pateraki, Lea Richard, Pim Kolkman, Maria Fátima Lucas, Victor Guallar, Ric C.H. de Vos, Maurice C. R. Franssen, Alexander van der Krol, Harro Bouwmeester
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06565-8

Internet

https://doi.org/10.1038/s41467-018-06565-8

Similar Items