Role of Protein Kinase C (PKC) in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy

Role of Protein Kinase C (PKC) in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy

The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture. This review focusses on the role of the Protein Kinase C family in podocytes and points out the differential roles of classical...

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Bibliographic Details
Main Authors: Beina eTeng, Michelle eDuong, Irini eTossidou, Xuejiiao eYu, Mario eSchiffer
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Endocrinology
Subjects:
Proteinuria
glomerulosclerosis
diabetic podocytopathy
nephrin endocytosis
effacement
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00179/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00179/full

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