20-HETE Inhibition by HET0016 Decreases the Blood–Brain Barrier Permeability and Brain Edema After Traumatic Brain Injury

20-HETE Inhibition by HET0016 Decreases the Blood–Brain Barrier Permeability and Brain Edema After Traumatic Brain Injury

Recent studies have implicated 20-HETE as a vasoconstrictive mediator in trauma, the purpose of this study was to determine whether administration of HET0016, the 20-HETE inhibitor, could protect neurons from trauma and the effect of HET0016 on the blood–brain barrier (BBB) and brain edema in experi...

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Bibliographic Details
Main Authors: Liyan Lu, Mingliang Wang, Xiaoer Wei, Wenbin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
HET0016
blood–brain barrier
blood edema
20-HETE
traumatic brain injury
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00207/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00207/full

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