RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

Summary: Recent data suggest that therapy-resistant quiescent cancer stem cells (qCSCs) are the source of relapse in colon cancer. Here, using colon cancer patient-derived organoids and xenografts, we identify rare long-term label-retaining qCSCs that can re-enter the cell cycle to generate new tumo...

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Bibliographic Details
Main Authors: Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Ralf Lesche, Joern Toedling, Thibaud Jourdan, Johannes Haybaeck, Dominik Mumberg, David Henderson, Balázs Győrffy, Christian R.A. Regenbrecht, Ulrich Keilholz, Reinhold Schäfer, Martin Lange
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Cancer stem cells
Quiescence
Organoids
Colon cancer
p53 signaling
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221005861

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http://www.sciencedirect.com/science/article/pii/S2589004221005861

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