In vitro potency of 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione against drug-resistant and non-replicating persisters of Mycobacterium tuberculosis

In vitro potency of 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione against drug-resistant and non-replicating persisters of Mycobacterium tuberculosis

ABSTRACT: Objectives: New antituberculosis agents active against drug-resistant and non-replicating tubercle bacilli are required. We evaluated a previously identified hit, 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione (PAMCHD), against several clinical Mycobacterium tuber...

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Bibliographic Details
Main Authors: Muzafar Ahmad Rather, Zubair Shanib Bhat, Ali Mohd Lone, Mubashir Maqbool, Bilal Ahmad Bhat, Zahoor Ahmad
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
PAMCHD
Multidrug-resistant TB
Mycobacterium tuberculosis
Resistance
Tolerance
Persistence
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716521000813

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http://www.sciencedirect.com/science/article/pii/S2213716521000813

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