Genome-Wide Analysis Reveals Hypoxic Microenvironment Is Associated With Immunosuppression in Poor Survival of Stage II/III Colorectal Cancer Patients

Genome-Wide Analysis Reveals Hypoxic Microenvironment Is Associated With Immunosuppression in Poor Survival of Stage II/III Colorectal Cancer Patients

Background: Hypoxia is associated with a poorer clinical outcome and resistance to chemotherapy in solid tumors; identifying hypoxic-related colorectal cancer (CRC) and revealing its mechanism are important. The aim of this study was to assess hypoxia signature for predicting prognosis and analyze r...

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Bibliographic Details
Main Authors: Yu-feng Chen, Zhao-liang Yu, Min-yi Lv, Bin Zheng, Ying-xin Tan, Jia Ke, Xuan-hui Liu, Ze-rong Cai, Yi-feng Zou, Ping Lan, Xiao-jian Wu, Feng Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Medicine
Subjects:
hypoxia-related gene signature
immunosuppression
chemoresistance
colorectal cancer
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.686885/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.686885/full

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