Cathepsin K knockout protects against cardiac dysfunction in diabetic mice

Abstract Diabetes is a major risk factor for cardiovascular disease and the lysosomal cysteine protease cathepsin K plays a critical role in cardiac pathophysiology. To expand upon our previous findings, we tested the hypothesis that, knockout of cathepsin K protects against diabetes-associated card...

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Bibliographic Details
Main Authors: Rui Guo, Yinan Hua, Olivia Rogers, Travis E. Brown, Jun Ren, Sreejayan Nair
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09037-z