AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

Abstract Background Extracellular aggregation of the amyloid-β (Aβ) peptide into toxic multimers is a key event in Alzheimer’s disease (AD) pathogenesis. Aβ aggregation is concentration-dependent, with higher concentrations of Aβ much more likely to form toxic species. The processes that regulate ex...

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Bibliographic Details
Main Authors: Jane C. Hettinger, Hyo Lee, Guojun Bu, David M. Holtzman, John R. Cirrito
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Amyloid-beta
AMPA
Clearance
IL-6
Microdialysis
Online Access:http://link.springer.com/article/10.1186/s13024-018-0256-6

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http://link.springer.com/article/10.1186/s13024-018-0256-6

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