Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells

Glucose is an important inducer of insulin secretion, but it also stimulates long-term adaptive changes in gene expression that can either promote or antagonize the proliferative potential and function of β cells. Here, we have generated time-resolved profiles of enhancer and transcriptional activit...

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Bibliographic Details
Main Authors: Søren Fisker Schmidt, Jesper Grud Skat Madsen, Kari Østerli Frafjord, Lars la Cour Poulsen, Sofia Salö, Michael Boergesen, Anne Loft, Bjørk Ditlev Larsen, Maria Stahl Madsen, Jens Juul Holst, Pierre Maechler, Louise Torp Dalgaard, Susanne Mandrup
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Subjects:
metabolism
pancreatic β cells
β cells
proliferation
glucose
ChREBP
RORγ
ChIP-seq
RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716309949

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