Jens Juul Holst

Jens Juul Holst (born 1 August 1945) is a Danish physician and physiologist. He is known for discovering and describing the hormone glucagon-like peptide-1 (GLP-1), a hormone in the gut that plays an important role in the onset and development of Type 2 diabetes. In collaboration with researcher and author Arne Astrup, he discovered that GLP-1 acts as a satiety hormone in humans.

In 2020, he was awarded the Warren Alpert Foundation Prize along Daniel J. Drucker and Joel F. Habener.

In 2021, he was awarded the Canada Gairdner International Award along Daniel J. Drucker, Joel F. Habener, and Mary-Claire King. He was also awarded the Banting Medal by the American Diabetes Association (ADA).

In 2024, he was awarded the Princess of Asturias Awards for Technical and Scientific Research along Daniel J. Drucker, Jeffrey M. Friedman, Joel F. Habener, and Svetlana Mojsov. and also in 2024 he received the Tang Prize in the category of "Biopharmaceutical Science". Provided by Wikipedia
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  1. 1
    From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy
    by Jens Juul Holst
    Published 2019-04-01
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    Article
  2. 2
    What combines best with GLP-1 for obesity treatment: GIP receptor agonists or antagonists?
    by Jens Juul Holst
    Published 2021-05-01
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  3. 3
    Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches
    by Geke Aline Boer, Jens Juul Holst
    Published 2020-12-01
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    Article
  4. 4
    Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial
    by Ann Bjørnshave, Jens Juul Holst, Kjeld Hermansen
    Published 2018-01-01
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    Article
  5. 5
    Peptone‐mediated glucagon‐like peptide‐1 secretion depends on intestinal absorption and activation of basolaterally located Calcium‐Sensing Receptors
    by Ida M. Modvig, Rune E. Kuhre, Jens Juul Holst
    Published 2019-04-01
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    Article
  6. 6
    Effect of oral contraceptives and/or metformin on GLP-1 secretion and reactive hypoglycaemia in polycystic ovary syndrome
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    Article
  7. 7
    Dietary Fiber Is Essential to Maintain Intestinal Size, L-Cell Secretion, and Intestinal Integrity in Mice
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  8. 8
    Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats
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  9. 9
    Do glucagonomas always produce glucagon?
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  10. 10
    GLP-1 and Intestinal Diseases
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  11. 11
    GIP-induced vasodilation in human adipose tissue involves capillary recruitment
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  12. 12
    Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors
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  13. 13
    Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment
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  14. 14
    Glucagon‐like peptide‐1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP‐1 receptors
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  15. 15
    The Effect of Dietary Fish Oil in addition to Lifestyle Counselling on Lipid Oxidation and Body Composition in Slightly Overweight Teenage Boys
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  16. 16
    Functional and Immunohistochemical Evaluation of Porcine Neonatal Islet-Like Cell Clusters
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  17. 17
    The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes
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  18. 18
    Instrumentalization of Eating Improves Weight Loss Maintenance in Obesity
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  19. 19
    Endogenous glucagon-like peptide- 1 and 2 are essential for regeneration after acute intestinal injury in mice.
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  20. 20
    Increased postprandial glycaemia, insulinemia, and lipidemia after 10 weeks’ sucrose-rich diet compared to an artificially sweetened diet: a randomised controlled trial
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