Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease

Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease

The pathogenesis of Alzheimer's disease (AD) is correlated with the misfolding and aggregation of amyloid-beta protein (Aβ). Here we report that the antibiotic benzylpenicillin (BP) can specifically bind to Aβ, modulate the process of aggregation and supress its cytotoxic effect, initially via...

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Bibliographic Details
Main Authors: Izzeddin Alsalahat, Zubida M. Al-Majdoub, Mutasem O. Taha, Jill Barber, Harmesh Aojula, Nigel Hodson, Sally Freeman
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Alzheimer's disease
Amyloid-beta
Benzylpenicillin
Thioflavin T
Atomic force microscopy
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821000376

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http://www.sciencedirect.com/science/article/pii/S2405580821000376

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