Dendrobium nobile Lindl. Alkaloids Decreases the Level of Intracellular β-Amyloid by Improving Impaired Autolysosomal Proteolysis in APP/PS1 Mice

Dendrobium nobile Lindl. Alkaloids Decreases the Level of Intracellular β-Amyloid by Improving Impaired Autolysosomal Proteolysis in APP/PS1 Mice

As the major degradation pathway for long-lived proteins and organelles, macroautophagy is a decisive factor for the survival and longevity of cells. The existing evidence indicates that the disruption of substrate proteolysis in autolysosomes is the main mechanism underlying autophagy failure in Al...

Full description

Bibliographic Details
Main Authors: Jing Nie, Lin-Shan Jiang, Yu Zhang, Yong Tian, Li-Sheng Li, Yan-Liu Lu, Wen-Jin Yang, Jing-Shan Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
Dendrobium nobile Lindl. alkaloids
alzheimer’s disease
β-amyloid peptide
macroautophagy
lysosomal acidification
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01479/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01479/full

Similar Items