Elevated Glucose and Insulin Levels Decrease DHA Transfer across Human Trophoblasts via SIRT1-Dependent Mechanism

Elevated Glucose and Insulin Levels Decrease DHA Transfer across Human Trophoblasts via SIRT1-Dependent Mechanism

Gestational diabetes mellitus (GDM) results in reduced docosahexaenoic acid (DHA) transfer to the fetus, likely due to placental dysfunction. Sirtuin-1 (SIRT1) is a nutrient sensor and regulator of lipid metabolism. This study investigated whether the high glucose and insulin condition of GDM regula...

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Bibliographic Details
Main Authors: Jay S. Mishra, Hanjie Zhao, Sari Hattis, Sathish Kumar
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Nutrients
Subjects:
gestational diabetes
DHA
fatty acid transport
lipid metabolism
CD36
FABP3
Online Access:https://www.mdpi.com/2072-6643/12/5/1271

Internet

https://www.mdpi.com/2072-6643/12/5/1271

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