Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon.

FGFR1 amplification occurs in ~20% of sqNSCLC and trials with FGFR inhibitors have selected FGFR1 amplified patients by FISH. Lung cancer cell lines were profiled for sensitivity to AZD4547, a potent, selective inhibitor of FGFRs 1-3. Sensitivity to FGFR inhibition was associated with but not wholly...

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Main Authors: Claire Rooney, Catherine Geh, Victoria Williams, Johannes M Heuckmann, Roopika Menon, Petra Schneider, Katherine Al-Kadhimi, Michael Dymond, Neil R Smith, Dawn Baker, Tim French, Paul D Smith, Elizabeth A Harrington, J Carl Barrett, Elaine Kilgour
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4764357?pdf=render